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基于包膜超声造影微泡在超声场中的理论振动模型,对其次谐波特性进行优化设计,从理论上计算和分析了微泡粒径、膜弹性及声压等对微泡次谐波响应的影响,以期获得其用于非破坏性次谐波成像的最佳条件。另外通过改变膜材料的配比, 制备了具有不同膜弹性的超声造影微泡,对其声学特性进行了体外声学实验测定。仿真计算和实验结果表明,在合适的膜材料配比条件下,制得的平均粒径为3μm左右的包膜微泡,可获得满意的次谐波响应,并且其用于非破坏性次谐波成像时的最佳工作声压约200-400 kPa。
Based on the theoretical vibration model of ultrasound-guided microbubbles in ultrasound field, the second harmonic characteristic was optimized, and the effects of particle size, membrane elasticity and sound pressure on the sub-harmonic response of microbubbles were calculated and analyzed theoretically In order to obtain the best conditions for non-destructive sub-harmonic imaging. In addition, ultrasound contrast microbubbles with different membrane elasticity were prepared by changing the ratio of membrane materials, and their acoustic properties were measured by in vitro acoustics. The simulation results and the experimental results show that the submicron response can be obtained with the average particle size of about 3μm under the condition of the proper film material ratio and its application to non-destructive subharmonic The best working sound pressure during wave imaging is about 200-400 kPa.