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一般认为抗酸剂治疗消化性溃疡的作用是通过中和酸并灭活胃蛋白酶实现的。近年的研究提示可能还有其他作用,如细胞保护。本文观察了抗酸剂及一些隋性化物的细胞保护作用,并以硫糖铝作对照,后者能促进内源性前列腺素E_2(PGE_2)分泌,具有细胞保护作用。材料和方法:雄性大鼠每组10只。在禁食18小时后,胃内给予悬浮药液。用96％乙醇造成胃粘膜损伤。另有两组在给氢氧化铝凝胶2000mg/kg和硫糖铝500mg/kg之前30分钟,先皮下注射消炎痛。给乙醇60分钟后处死动物,将胃切开,用计算机控制的图象扫描系统测定胃粘膜损伤的程度。收集胃液测定渗透压和
Antacids are generally considered to be effective in treating peptic ulcer by neutralizing acid and inactivating pepsin. Recent studies suggest that there may be other effects, such as cytoprotection. In this paper, we observed the cytoprotective effects of antacids and some of them, and compared with sucralfate, the latter could promote the secretion of endogenous prostaglandin E_2 (PGE_2) with cell protection. Materials and Methods: Male rats, each group of 10. After fasting for 18 hours, the suspension was administered intragastrically. Gastric mucosal injury with 96% ethanol. The other two groups were given subcutaneous injections of indomethacin 30 minutes prior to giving aluminum hydroxide gel 2000 mg / kg and sucralfate 500 mg / kg. The animals were sacrificed 60 minutes after the ethanol was given, the stomach was dissected and the degree of gastric mucosal damage was determined using a computer-controlled image scanning system. Gastric juice was collected to determine osmotic pressure