作者在以往工作的基础上,采用体内外试验观察了槲皮素对血小板的作用。结果发现,槲皮素可显著抑制二磷酸腺苷、胶原、钙离子载体和花生四烯酸诱导的血小板聚集及血小板5—羟色胺的释放反应;槲皮素能减少血小板血栓烷B_2量、升高6—酮—前列腺素F_(1α)量和6—酮—前列腺素F_(1α)/血栓烷B_2的比值。初步探讨了槲皮素的作用机理,认为其主要是通过影响ADP 和TXA_2途径抑制血小板活化。 Based on previous work, the authors used in vitro and in vivo experiments to observe the effect of quercetin on platelets. The results showed that quercetin can significantly inhibit adenosine diphosphate, collagen, calcium ionophore and arachidonic acid induced platelet aggregation and platelet serotonin release response; quercetin can reduce platelet thromboxane B 2 content, increased The ratio of 6-keto-prostaglandin F 1 alpha and 6-keto-prostaglandin F 1 alpha/thromboxane B 2 . The mechanism of action of quercetin was preliminarily investigated, and it was thought that it mainly inhibits platelet activation through affecting the ADP and TXA 2 pathways.