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目的:探讨乙酰胆碱酯酶活性改变在重症肌无力(MG)发病中的作用。方法:采用三氯化铁显色分光光度比色分析法分别检测50例不同型MG患者与正常人血浆乙酰胆碱酯酶(P-AchE)、红细胞乙酰胆碱酯酶(E-AchE)活性。结果:患者组的P-AchE平均活性和E-AchE活性显著高于对照组,而且与重症肌无力临床类型和病情轻重有关,病情越重,其活性越高。结论:重症肌无力的发病机制除自身免疫因素外,乙酰胆碱酯酶活性改变也是一个重要因素,P-AchE和E-AchE活性测定可作为MG的一项辅助诊断方法,也可作为抗胆碱酯酶药物疗效观察指标。
Objective: To investigate the role of acetylcholinesterase activity in the pathogenesis of myasthenia gravis (MG). Methods: The levels of acetylcholinesterase (P-AchE) and erythrocyte acetylcholinesterase (E-AchE) in 50 MG patients and normal subjects were detected by colorimetry with ferric chloride. Results: The average activity of P-AchE and activity of E-AchE in patients were significantly higher than those in control group, but were also related to the clinical type and severity of myasthenia gravis. The heavier the disease, the higher the activity. Conclusion: The pathogenesis of myasthenia gravis in addition to autoimmune factors, changes in acetylcholinesterase activity is also an important factor, P-AchE and E-AchE activity assay can be used as an adjunct to MG diagnosis, but also as an anticholinergic Enzyme drug efficacy indicators.