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对54例异常核型者和30名对照作紫外线诱导姊妹染色单体交换及低叶酸诱导染色体脆性部位表达和微核检测，发现异常核型者三项实验数值限（8．75±2．14／细胞、3．89±1．18％、7．30±1．98％）比对照（6．13±1．03／细胞、2．03±0．72％、4．50±1．11％）有极显著性增加，提示在不良环境因素中，异常核型者更易发生染色体畸变。
Fifty-four abnormal karyotypes and 30 controls were used for UV-induced sister chromatid exchange and low folate-induced chromosomal fragile site expression and micronucleus test. The three experimental numerical limits (8.75 ± 2.14 / Cell, 3.89 ± 1.18%, 7.30 ± 1.98%) than the control (6.13 ± 1.03 / cell, 2.03 ± 0.72%, 4.50 ± 1.11 %) Showed a very significant increase, suggesting that in adverse environmental factors, aberrant karyotype more prone to chromosomal aberrations.