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受试者是37名健康成人,HBV血清学标志为阴性、谷丙转氨酶(ALT)水平正常,没有接受过乙型肝炎疫苗。酵母重组乙型肝炎疫苗系adw亚型,用层析法纯化。纯化的HBsAg用甲醛处理,铝佐剂吸附,每ml含10μgHBsAg。
The subjects were 37 healthy adults with negative HBV serology and normal alanine aminotransferase (ALT) levels and no hepatitis B vaccine. Yeast recombinant hepatitis B vaccine adw subtype, purified by chromatography. Purified HBsAg was treated with formaldehyde and adsorbed on aluminum adjuvant containing 10 μg HBsAg per ml.