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目的探讨胎盘葡萄糖转运蛋白(glucosetransporter,GLUT)的表达在胎儿生长受限(fetalgrowthrestriction,FGR)发生发展中的作用及其与孕妇血清皮质醇(cortisol,CORT)水平的相关性。方法用免疫组织化学法检测20例FGR孕妇(FGR组)及24例正常妊娠孕妇(对照组)胎盘GLUT1的表达。利用放射免疫分析法测定两组孕妇产前血清CORT水平。同时测量新生儿出生体重和胎盘重量。结果FGR胎盘GLUT1表达水平(149.8±8.2)较对照组(155.9±6.5)明显降低(P<0.05),胎盘合体滋养层基底膜面GLUT1的表达水平(135.3±4.2)较对照组(153.9±8.5)明显降低(P<0.01)。胎盘GLUT1表达水平与孕妇血清CORT水平呈负相关(r=-0.803,P<0.01)。结论胎盘组织中,特别是基底膜面的GLUT1表达水平下降可能是FGR的病因之一,CORT可能通过抑制胎盘GLUT1的表达,参与FGR的发病过程。
Objective To investigate the role of placental glucose transporter (GLUT) expression in the development of fetal growth restriction (FGR) and its relationship with serum cortisol (CORT) levels in pregnant women. Methods The placental GLUT1 expression in 20 FGR pregnant women (FGR group) and 24 normal pregnant women (control group) was detected by immunohistochemistry. Pretreatment serum CORT levels were measured by radioimmunoassay in both groups. Simultaneous measurement of newborn birth weight and placental weight. Results The expression level of GLUT1 in the placenta of FGR was significantly lower than that in the control group (149.8 ± 8.2) (155.9 ± 6.5) (P <0.05). The GLUT1 expression level in the placental syncytiotrophoblast was (135.3 ± 4.2) ) Was significantly lower (P <0.01). The expression of GLUT1 in placenta was negatively correlated with serum CORT level in pregnant women (r = -0.803, P <0.01). Conclusion The decrease of GLUT1 expression in placenta may be one of the causes of FGR. CORT may participate in the pathogenesis of FGR by inhibiting the expression of GLUT1 in the placenta.