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为了解新生儿患儿肾小管功能变化，应用ＥＬＩＳＡ法检测３６ 例新生儿硬肿症患儿尿视黄醇结合蛋白（ＲＢＰ）。结果显示硬肿症患儿尿ＲＢＰ明显高于对照组（ Ｐ＜ ０．０１） ，中、重度硬肿症组均高于对照组（ Ｐ＜０ ．０５ ，Ｐ＜ ０．０１） 。而轻度硬肿症组与对照组的差异无显著性（ Ｐ＞ ０ ．０５） ，提示中、重度新生儿硬肿症患儿存在有肾小管功能的损害。
Urinary retinol binding protein (RBP) was detected in 36 neonates with sclerodema by ELISA in order to understand the changes of renal tubular function in neonates. The results showed that urinary RBP in children with scleredema was significantly higher than that in the control group (P <0.01), moderate and severe sclerosis group was higher than the control group (P <0.05, P <0.01). The mild scleredema group and the control group was no significant difference (P> 0.05), suggesting that severe neonatal sclerema renal tubular function exists damage.