胰岛素抵抗(IR)是指一定量的胰岛素所产生的生物学效价低于正常预计水平；机体代偿性地分泌过多的胰岛素。临床上常表现为高胰岛素血症和糖耐量减低。1987年Ferrannini等第一次用正常血糖胰岛素钳夹技术证实原发性高血压患者存在IR。1988年Reaven提出IR与高血压具相关性后,许多学者对其进行了研究。近年来,大量研究报道高血压和IR的关 Insulin resistance (IR) refers to the amount of insulin produced by the biological titers lower than the normal expected level; the body compensatory secretion of excess insulin. Clinically often manifested as hyperinsulinemia and impaired glucose tolerance. In 1987, Ferrannini et al. First confirmed the presence of IR in patients with essential hypertension by using normal glucose insulin clamp technique. Reaven proposed IR in 1988 and hypertensive correlation, many scholars have studied it. In recent years, a large number of studies report the relationship between hypertension and IR