论文部分内容阅读
目的探讨甲状腺机能减退症(甲减)患者左旋甲状腺激素(L-T4)治疗前后血浆护骨素(OPG)水平的变化。方法选择20例临床甲减、20例亚临床甲减患者和20例健康者(对照组)。所有甲减患者采用 L-T4补充治疗至甲状腺功能在正常范围内。血浆 OPG 采用酶联免疫法测定。结果 L-T4治疗前,临床甲减组和亚临床甲减组血浆 OPG 水平分别为3.13 ng/L±0.27 ng/L 和2.95ng/L±0.24 ng/L,明显高于对照组(2.42 ng/L±0.26 ng/L,P=0.000),多元相关分析结果显示,OPG与 TSH 呈正相关(r=0.306,P<0.05),与内皮依赖性血管舒张功能呈负相关(r=-0.675,P<0.01)。治疗至甲状腺功能正常后,2组血浆 OPG 水平明显降低(2.53 ng/L±0.28 ng/L,2.54 ng/L±0.21 ng/L,P=0.000),与对照组相近。治疗前后 OPG 的变化与 TSH 的变化呈正相关(P<0.05),与内皮依赖性血管舒张功能呈负相关(P<0.01)。与其他指标的变化无关。结论 OPG 可能是甲减患者血管内皮功能的重要调节分子。
Objective To investigate the changes of plasma osteoprotegerin (OPG) levels in patients with hypothyroidism (hypothyroidism) before and after L-T4 treatment. Methods 20 cases of clinical hypothyroidism, 20 cases of subclinical hypothyroidism and 20 cases of healthy subjects (control group). All patients with hypothyroidism using L-T4 supplementation to thyroid function within the normal range. Plasma OPG was measured by enzyme-linked immunosorbent assay. Results The levels of OPG in clinical hypothyroidism group and subclinical hypothyroidism group were 3.13 ng / L ± 0.27 ng / L and 2.95 ng / L ± 0.24 ng / L before L-T4 treatment, which were significantly higher than those in control group (2.42 ng / /L ± 0.26 ng / L, P = 0.000). Multivariate correlation analysis showed that OPG was positively correlated with TSH (r = 0.306, P <0.05) and negatively correlated with endothelium-dependent vasodilation (r = -0.675, P <0.01). After treatment to normal thyroid function, plasma OPG levels were significantly decreased in both groups (2.53 ng / L ± 0.28 ng / L, 2.54 ng / L ± 0.21 ng / L, P = 0.000), similar to the control group. Changes of OPG before and after treatment were positively correlated with changes of TSH (P <0.05), and negatively correlated with endothelium-dependent vasodilation (P <0.01). Has nothing to do with changes in other indicators. Conclusion OPG may be an important regulatory molecule of vascular endothelial function in patients with hypothyroidism.