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目的观察大剂量丙种球蛋白治疗川崎病的疗效。方法 3 9例住院患儿随机分为两组。治疗组 :在常规治疗的基础上 ,加用大剂量丙种球蛋白静脉滴注 ,对照组 :采用常规方法治疗。结果治疗组与对照组热程分别为 (9.19± 2 .5 6)和 (12 .3 0± 5 .3 5 )天 ,治疗组较对照组明显缩短 (P<0 .0 5 )。而冠状动脉损害发生率治疗组 (5 .3 % )亦显著低于对照组 (3 0 % )。结论早期使用大剂量静脉滴注丙种球蛋白治疗川崎病 ,可以缩短热程 ,明显减少冠状动脉损害的发生率。
Objective To observe the efficacy of high-dose gamma globulin in the treatment of Kawasaki disease. Methods 39 hospitalized children were randomly divided into two groups. Treatment group: On the basis of conventional treatment, plus high-dose gamma globulin intravenous infusion, the control group: the use of conventional methods of treatment. Results The thermal histories of the treatment group and the control group were (9.19 ± 2.56) days and (12.3 ± 5.55 days), respectively. The treatment group was significantly shorter than the control group (P <0.05). The incidence of coronary artery injury in the treatment group (5.3%) was also significantly lower than the control group (30%). Conclusion Early use of high-dose intravenous gamma globulin treatment of Kawasaki disease, can shorten the heat stroke, significantly reduce the incidence of coronary artery lesions.