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把膜蛋白作为菌苗成分可有不同形式,蛋白-去污剂复合物是一种简单的具有较高免疫原性的结构,本文报道了对含两性去污剂的B群脑膜炎球菌菌苗的短期毒性研究。作者将40～60g雄性大鼠随机分成4组,每组6只。试验组肌注浓度分别为25μg或50μg蛋白/ml的B群脑膜炎球菌菌苗(含两性去污剂75μg/ml),比较组接种DTP-脊髓灰质炎疫苗,对照组注射磷酸盐缓冲液(PBS),在0日和7日于左右侧股四头肌处肌注0.25ml试验溶液,第14日麻醉采血,作血液学检查。分离左右侧腹股沟淋巴结称重,对这些淋巴
Membrane proteins as vaccine components can have different forms, protein - detergent complex is a simple structure with higher immunogenicity, reported in this paper, with gender amphoteric B group meningococcal vaccine Short-term toxicity studies. The authors will be 40 ~ 60g male rats were randomly divided into 4 groups of 6. Group B meningococcal vaccine (containing amphoteric detergent 75μg / ml) was intramuscularly injected into the experimental group at 25μg or 50μg protein / ml, and the control group was inoculated with the DTP-polio vaccine and the control group received phosphate buffered saline PBS), 0.25 ml test solution was intramuscularly injected on the left and right quadriceps on days 0 and 7, and the blood was anesthetized on the 14th for hematology examination. Left and right inguinal lymph nodes were separated and weighed against these lymph nodes