目的:探讨可调控双向引流型封闭负压在难愈性创面治疗中的效果。方法:对2014年3月-2016年5月我科收治的51例非手术治疗难愈性皮肤软组织缺损患者,采用可调控双向引流型封闭负压治疗。结果:经过12~55天,平均23.5日的治疗,51例患者创面愈合良好,15例感染创面换药1-2次后细菌培养呈阴性,未发现新增感染创面。结论:可调控双向引流型封闭负压治疗在确保难愈性创面治疗效果的同时,提高患者换药间隔,减少住院费用,提高患者满意度,值得推广应用。 Objective: To investigate the effect of two-way drainage closed negative pressure in the treatment of refractory wounds. Methods: From March 2014 to May 2016, 51 cases of non-surgical treatment of refractory skin and soft tissue defects treated in our department were treated with controlled bidirectional drainage closed negative pressure therapy. Results: After 12 to 55 days with an average of 23.5 days of treatment, wound healing of 51 patients was good. Bacterial culture was negative after 15 wounds were changed 1-2 times. No newly-infected wounds were found. Conclusion: The two-way drainage closed negative pressure therapy can improve the curative effect of refractory wounds, improve the patient dressing intervals, reduce hospitalization costs and improve patient satisfaction, which is worth popularizing and applying.