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本文的目的是研究肝硬化住院病人中肺炎球菌菌血症的发生率、易感环境和致死因素。作者对巴黎某大学附属医院3年来诊断为肺炎球菌菌血症的100例病人进行了回顾性研究,发现22例(22%)发生在肝硬化患者。其中16例(72%)是酒精性肝硬化。16例中有12例(75%)同时存在急性酒精性肝炎的病变。肺炎球菌菌血症在非肝硬化者的发病率为0.12%,在肝硬化者为1.42%(P<0.001),而在有急性酒精性肝炎病变的肝硬化者则高达5.05%(P<0.01)。在第1次血培养为阳性的当天,71%的肝硬化病人有黄疽,95%有腹水,52%有肝性脑病。
The purpose of this article is to study the incidence of pneumococcal bacteremia, susceptible environments and lethal factors in hospitalized patients with cirrhosis. The authors performed a retrospective study of 100 patients diagnosed with pneumococcal bacteremia in a university-affiliated hospital in Paris in 3 years and found that 22 (22%) patients had cirrhosis. Of these, 16 (72%) were alcoholic cirrhosis. Twelve of the 16 patients (75%) had lesions of acute alcoholic hepatitis. The incidence of pneumococcal bacteremia was 0.12% in non-cirrhotic patients and 1.42% in cirrhotic patients (P <0.001), while it was 5.05% in cirrhotic patients with acute alcoholic hepatitis (P <0.01 ). On the day the first blood culture was positive, 71% of cirrhotic patients had jaundice, 95% had ascites, and 52% had hepatic encephalopathy.