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目的探讨小儿异基因造血于细胞移植并发间质性肺炎（IP）的发病病因、临床特点、危险因素及防治措施。方法根据尸解病理检查及聚合酶键反应技术对病毒病原学检测结果，结合临床移植资料综合分析。结果14例移植患儿中并发IP3例（3／14），分别死于十19天、＋76天、＋150天;3例IP中2例移植前后外周血及尸解肺组织直到CMV包涵体;4例3～4应急性GVHD患儿中3例并发IP，10例0～2度急性GVHD无1例并发IP。结论IP是移植早期死亡的重要原因之一，巨细胞病毒感染是IP的主要病原，GVHD严重程度与移植后并发IP密切相关.
Objective To investigate the etiological factors, clinical features, risk factors and prevention and treatment of pediatric allogeneic hematopoiesis in patients with interstitial pneumonia (IP). Methods According to autopsy pathology and polymerase chain reaction (PCR), the results of virus etiology were analyzed and combined with clinical data. Results 14 cases of IPT were complicated with IP3 (3/14) in 14 cases, and died in 10 days, + 76 days and + 150 days respectively. The peripheral blood and autopsy lung tissue in 2 of 3 IP patients were up to CMV inclusion body. 3 cases of patients with acute GVHD in 3 cases complicated by IP, 10 cases of 0 ~ 2 degrees of acute GVHD without IPE. Conclusions IP is one of the important causes of early transplant death. Cytomegalovirus infection is the main pathogen of IP. The severity of GVHD is closely related to the IP after transplantation.