一种内皮细胞产生的21个氨基酸残基的血管收缩肽——内皮素(endothelin)经分离已获得。实验证明,内皮索是迄今为止所知的最强的血管收缩物质之一,内皮素原前体的互补DNA的克隆和序列表明,具活性的内皮素经一不寻常的蛋白水解过程产生,是一组神经毒素的部分类似物,提示内皮素是 A 21 amino acid residue vasoconstrictor peptide, endothelin, produced by endothelial cells has been isolated. Experiments have shown that endothelium is one of the most potent vasoconstrictors known to date and the cloning and sequencing of the complementary DNA to the precursor of endothelin shows that active endothelin is produced by an unusual proteolytic process and is A group of neurotoxins analogues, suggesting that endothelin is