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目的 观察莨菪类生物碱对吗啡 (Mor)致小鼠依赖性作用的影响。方法 连续 7d腹腔注射Mor建立小鼠依赖模型。热板法用于反映莨菪类生物碱的中枢镇痛效应 ,计数纳络酮 (Nal)催促的动物跳跃次数和跳跃率来反映莨菪类生物碱减轻Mor的依赖症状。结果 Mor依赖组小鼠痛阈明显下降 ,跳跃次数明显增加。实验发现东莨菪碱 (4mg·kg-1× 7d)能明显提高Mor依赖小鼠的痛阈 ,并减少跳跃次数和跳跃动物率。阿托品和山莨菪碱提高Mor依赖小鼠的痛阈作用较弱减少跳跃次数和跳跃动物率的作用较强。结论 莨菪生物碱中 ,东莨菪碱在提高Mor依赖小鼠痛阈的作用最强有显著对抗吗啡致小鼠依赖性的作用。
Objective To observe the effects of alkaloids from scorpion on the morphine-induced mice. Methods The model of mice dependence was established by intraperitoneal injection of Mor for 7 days. The hot plate method is used to reflect the central analgesic effect of the alkaloids of the scopolamine alkaloids, and the numbers of jumps and jumps of animals driven by naloxone are counted to reflect that the alkaloids of scopolamine alleviates Mor dependent symptoms. Results The mice in Mor dependent group had a marked decrease in pain threshold and a significant increase in the number of jumps. Scopolamine (4mg · kg-1 × 7d) was found to significantly increase the pain threshold and reduce the number of jumping and jumping animals in Mor dependent mice. Atropine and Anisodamine Enhance the Pain-Threshold Effect of Mor-Dependent Mice Weakly Decrease the Number of Jumps and Jumping Animal Rates. Conclusion Scopolamine alkaloids, scopolamine in the Mor-dependent mice to increase the pain threshold of the strongest significant role in morphine-induced mice were dependent.