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本文比较研究了~(14)C-棉酚在小鼠、大鼠、犬和猴体内的吸收、分布和排泄过程。小鼠和大鼠于单次口服~(14)C-棉酚后6～9小时,血内放射性达高峰,生物半衰期分别为31和16.5小时。口服~(14)C-棉酚48小时后,以胃肠道内容物及肝、肾内放射性最高。睾丸内放射性大鼠比小鼠要高。进入体内~(14)C-棉酚,放射性排出主要通过粪便,少部分从尿排出。以犬和猴(各1只)进行比较研究,也获得类似结果。它们睾丸内放射性均比大鼠低。与其它三种动物比较,犬心脏内放射性最高,猴体内放射性从粪便中排出最快。本文结果提示棉酚对不同动物的抗生育作用与毒性作用之间的差异,可能与它在相应脏器内的分布、蓄积及排泄速度的不同有关。
This paper comparatively studied the absorption, distribution and excretion of ~ (14) C-gossypol in mice, rats, dogs and monkeys. After a single oral administration of ~ (14) C-gossypol, mice and rats reached their peak in intranasal radioactivity with biological half-life of 31 and 16.5 hours, respectively. Oral ~ (14) C-gossypol 48 hours later, the contents of the gastrointestinal tract and liver, kidney radioactive highest. Radioactive rats in testis are taller than mice. Into the body ~ (14) C-gossypol, mainly through the excretion of radioactive discharge, a small part of the urine discharged. A comparative study was also conducted with dogs and monkeys (one each), and similar results were obtained. They have lower testicular radioactivity than rats. Compared with the other three animals, the highest radioactivity was found in the dog’s heart and the radioactivity in the monkey was the fastest from the stool. Our results suggest that the differences between gossypol resistance and toxicity in different animals may be related to the different distribution, accumulation and excretion rates of gossypol in different organs.