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Objective To investigate early changes in systemic rnand splanchnic hemodynamics after orthotopic liver rntransplantation (OLT) in normal and cirrhotic rats.rnMethods Male Sprague-Dawley rats were divided into rn4 groups:normal controls (NL,n=10),intrahepatic rnportal hypertension (IHPH, n=10) induced by injection rnof CCl4, normal rats with OLT (NL-OLT,n=9) and rnIHPH rats with OLT (IHPH-OLT,n=16). IHPH-OLT rnrots were divided into 2 subgroups: 3 days (Group A,rnn=9) and 7 days (Group B, n=7) after OLT. OLT rnwas pedormed in rats using cuffs for the anastomosis rnof the suprahepatic inferior vena cava,infrahepatic rnvena cava and portal vein. Two weeks after production rnof IHPH rots, 7 days after NL-OLT rats, 3 days and 7 rndays after IHPH-OLT rats, radicective microspheres rnwere used in a hemodynamic study.rnResults There were no significant differences in rnhemodynamic changes between NL-OLT and NL rets,rnexcept mean arterial blood pressure (MAP).The rncharacteristies of systemic and splanchnic rnhyperdynamic circulatory slate,including increased rncardiac output and splanchnic blood flow, decreased rnmean acterial blood pressure, total peripheral vascular rnresistance and splanchnic vascular resistance were rnibserved in IHPH, IHPH-OLT A, and IHPH-OLT B rnrats,The magnitude of hyperhemodynamics was in the rnorder of IHPH＞IHPH-OLT A＞IHPH-OLT B rats.rnMoreover, the derangement of splanchnic hyperrnhemodynamice was more significant than that of rnsystemic hyperhemodynamics.rnConclusioos The present study demonstrates that rnthe persistence of early systemic and splanchnic rnhyperkinetic circulation after OLT may be the rnconsequence of factors which maintain hyperhemorndynamics in liver cirrhosis, where portal hypertension is rnnot completely eliminated. Hyperhemodynamics is not rninduced by OLT per se.