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目的 :观察碱性成纤维细胞生长因子 ( b FGF)及成纤维细胞生长因子受体 ( FGFR)在豚鼠前庭终器的定位和表达。方法 :免疫组织化学。结果 :b FGF位于支持细胞和毛细胞的胞浆及胞核 ,FGFR位于支持细胞表面。b FGF及 FGFR在成年豚鼠表达较弱 ,新生豚鼠及庆大霉素内耳损伤豚鼠表达较强。结论 :提示 b FGF在豚鼠前庭终器发育、结构功能维持及损害后修复中起重要作用
Objective: To observe the localization and expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor (FGFR) in guinea pig vestibular end-devices. Methods: Immunohistochemistry. Results: b FGF is located in the cytoplasm and nucleus of supporting cells and hair cells, and FGFR is on the surface of supporting cells. b FGF and FGFR expression in adult guinea pigs is weak, neonatal guinea pigs and gentamicin inner ear guinea pigs express strong expression. CONCLUSIONS: This suggests that b FGF plays an important role in guinea pig vestibular end-stage development, structural function maintenance, and post-lesion repair