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应用ＳＤ大鼠作一侧肾切除术加重复阿霉素注射，首次阿霉素注射后２月，６０％肾小球产生节段性硬化，３月几乎全部肾小球呈节段性硬化伴少数球性硬化。实验大鼠有大量蛋白尿，低蛋白血症和高胆固醇血症，表现为典型的肾病综合征，后期血肌酐升高。该实验模型周期短、病变稳定、死亡率低，为一种有实用价值的加速性肾小球硬化实验模型。病理特征除有系膜增殖和肾小球硬化的一般改变外，尚有肾小球增大、毛细血管明显扩张、典型的微血管瘤，肾小球基底膜（ＧＢＭ）增厚和肾小动脉壁增厚，显示微血管病变及血液动力学改变在肾小球硬化过程中起重要作用，也进一步支持高灌注、高滤过、高血压和高代谢导致进行性肾小球硬化的观点。
Sprague-Dawley rats were used for side nephrectomy to increase the injection of doxorubicin, and 60% of glomeruli were segmental sclerosis in February after the first injection of doxorubicin. In March, almost all glomeruli were segmental sclerosis Minority of sclerosis. Experimental rats have a large number of proteinuria, hypoproteinemia and hypercholesterolemia, the performance of a typical nephrotic syndrome, elevated serum creatinine later. The experimental model of short cycle, stable disease, low mortality, is a practical model of accelerated glomerular sclerosis experimental model. In addition to the pathological features of mesangial proliferation and glomerulosclerosis in general changes, there are glomerular enlargement, significant dilation of capillaries, typical microvascular tumors, glomerular basement membrane (GBM) thickening and renal artery wall Thickening, showing microvascular changes and hemodynamic changes, play an important role in glomerulosclerosis and further support the notion that hyperperfusion, hyperfiltration, high blood pressure and high metabolism lead to progressive glomerulosclerosis.