钙增敏剂左西孟旦可在不显著增加心肌需氧量的前提下增加心肌收缩力,可用于慢性心力衰竭的急性失代偿期短期治疗。既往小型研究曾显示,在标准治疗基础上加用左西孟旦可改善感染性休克患者的血液动力学指标、微循环血流及肝肾功能。近期《新英格兰医学杂志》上发表的一项Ⅱ期随机双盲安慰剂对照临床研究显示,在标准治疗基础上加用左西孟旦并不能降低感染性休克成人患者的器官功能障碍的发病率或严重程度,反而会降低中断机械通 Calcium sensitizer levosimendan can increase myocardial contractility without significantly increasing myocardial oxygen demand, which can be used for short-term treatment of acute decompensated chronic heart failure. Previous small studies have shown that addition of levosimendan to standard therapy improves hemodynamic indices, microcirculation, and liver and kidney function in patients with septic shock. A recent phase II randomized double-blind placebo-controlled clinical study published in the New England Journal of Medicine found that the addition of levosimendin to standard therapy did not reduce the incidence of organ dysfunction in adult patients with septic shock Or severity, but will reduce the interruption of mechanical communication