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目的:明确从肿瘤内环境Ca~(2+)/Mg~(2+)同结肠癌患者预后及中医体质之间关系,以期探索中医药从调节体质、体内环境角度干预结肠癌预后可行性。方法:以2012年1月—2014年12月期间、在上海市中医医院就诊的结肠癌(Ⅲ、Ⅳ期)患者为研究对象,通过调查问卷及测定饮食、血清中Ca~(2+)/Mg~(2+),对其进行方差及Cox多因素模型分析。结果:(1)气虚型、阳虚型、血瘀型体质与血Ca~(2+)/Mg~(2+)存在统计学关联性,所有体质与食物Ca~(2+)/Mg~(2+)均无统计学关联性;(2)血清Ca~(2+)/Mg~(2+)每上升1个单位,肠癌患者的死亡风险上升2.35倍,食物Ca~(2+)/Mg~(2+)同死亡风险无统计学关联;(3)体质中仅血瘀质体质同结肠癌患者生存期有统计学意义。结论:肿瘤内环境Ca~(2+)/Mg~(2+)同结肠癌患者预后及中医体质之间相关,应通过中医药调整患者体质,改善肿瘤内环境,延长患者生存期。
OBJECTIVE: To clarify the relationship between the prognosis of Ca ~ (2+) / Mg ~ (2+) in patients with colon cancer and the constitution of Chinese medicine in order to explore the feasibility of traditional Chinese medicine (TCM) intervention in the prognosis of colon cancer. Methods: From January 2012 to December 2014, patients with colon cancer (stage Ⅲ and Ⅳ) attending Shanghai TCM Hospital were enrolled in this study. The questionnaire and diet were used to determine the serum level of Ca 2 + / Mg 2+, variance analysis and Cox multivariate model analysis. Results: (1) The constitution of Qi - deficiency type, Yang - yang - type and blood - stasis type had statistical relationship with Ca ~ (2 +) / Mg ~ (2) No correlation was found between the two groups. (2) The risk of death in patients with colorectal cancer increased by 2.35 times for every unit increase of serum Ca 2+ / Mg 2+ (2 + ) / Mg ~ (2 +) had no statistical significance with the risk of death; (3) There was significant difference in the survival of patients with blood stasis and colon cancer in constitution. Conclusion: The relationship between the intracumoral environment of Ca ~ (2 +) / Mg ~ (2+) and the prognosis of patients with colon cancer and the constitution of Chinese medicine should be adjusted by traditional Chinese medicine to improve the tumor environment and prolong the survival of patients.