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AT模体结合因子1(ATBF1)是一个新发现的抑癌基因,从人肝癌细胞HuH-7中分离得到。ATBF1可与甲胎蛋白基因增强子中AT富含原件结合,其表达产物是目前发现的分子量最大的转录调节因子。ATBF1基因表达过程中,通过选择性剪接产生ATBF1-A和ATBF1-B两种mRNA,这两种mRNA对AFP表达的调节具有相互对抗作用。ATBF1-A是ATBF1基因的主要表达形式,能抑制癌细胞生长;而ATBF1-B则能促进癌细胞增殖。ATBF1作为抑癌基因,为肿瘤的治疗带来新希望,但目前学术界对ATBF1的研究仍然有限。本文重点对ATBF1在神经系统、乳腺癌、胃癌、肝癌、结直肠癌以及其他肿瘤中的研究作综述,以期进一步明确ATBF1的抑癌机制。
AT motif binding factor 1 (ATBF1) is a newly discovered tumor suppressor gene isolated from human hepatoma HuH-7 cells. ATBF1 can bind to the AT-rich original in the alpha-fetoprotein gene enhancer, and its expression product is the highest molecular weight transcription regulator found so far. During the ATBF1 gene expression, two mRNAs, ATBF1-A and ATBF1-B, are produced by alternative splicing. These two mRNAs have antagonistic effects on the regulation of AFP expression. ATBF1-A is the main expression of ATBF1 gene, can inhibit the growth of cancer cells; while ATBF1-B can promote cancer cell proliferation. As a tumor suppressor gene, ATBF1 brings new hope for the treatment of cancer. However, the research on ATBF1 in the academic circles is still limited. This article focuses on the ATBF1 in the nervous system, breast cancer, gastric cancer, liver cancer, colorectal cancer and other tumors in the review, in order to further clarify the ATBF1 tumor suppressor mechanism.