食管静脉曲张破裂出血是肝硬化门脉高压症最严重的并发症之一,首次出血死亡率高达50～70％,反复出血发生率为80％。如何有效地控制大出血和预防反复出血,是一个重要的临床课题。1939年 Crafoord 和Frencener 首先介绍在食管镜下注射硬化剂治疗食管静脉曲张出血获得成功,但由于当时应用硬式会属食管镜,穿孔并发症较多,且需全麻,可加重肝损害, Esophageal variceal bleeding is one of the most serious complication of cirrhosis and portal hypertension, the mortality rate of the first bleeding is as high as 50 to 70% and the incidence of recurrent bleeding is 80%. How to effectively control bleeding and prevent repeated bleeding is an important clinical issue. In 1939 Crafoord and Frencener first introduced in the esophagoscopic sclerotherapy for the treatment of esophageal variceal bleeding success, but due to the application of hard-to-type esophagoscopy at the time, more perforation complications, and need general anesthesia, can aggravate liver damage,