皮肤隐球菌病在临床上是少见的,多发生于糖尿病、结核病、淋巴网状肉瘤、慢性淋巴细胞性白血病、何杰金氏病、肉样瘤病、慢性活动性肝炎、银屑病、类风湿性脊柱关节炎等患者中,亦可能认为是长期使用皮质激素的一种并发症.作者报道了一例极为罕见的原发性皮肤隐球菌病.患者女性、63岁,1976年8月底鼻翼部曾被蚊子叮咬,9月份局部出现一个溃疡结痂性损害,局部使用各种抗菌素与可的松软膏无效.皮损直径约1cm,界限清晰,边缘为红色堤状隆起,黑色焦痂下为溃疡并有少量溢脓.皮肤活检,霉菌学检查包括直接涂片,培养与生化检查支持新型隐球菌病的诊断,小白鼠腹膜内接种获阳性结果.患者一般化验检查无明显异常,血、尿、痰培养(-),胸片(-),血隐球菌培养(-),腰穿惜被拒绝.患者经100mg/kg 5- Skin cryptococcosis is clinically rare and occurs mostly in diabetes, tuberculosis, lymphatic sarcoma, chronic lymphocytic leukemia, Hodgkin’s disease, sarcoidosis, chronic active hepatitis, psoriasis, Rheumatoid arthritis and other patients, may also be considered as a long-term use of corticosteroid complications.A report of an extremely rare case of primary cutaneous cryptococcosis.Female female, 63 years old, at the end of August 1976 the nasal wing Had been bitten by mosquitoes, a local ulcer scab damage in September, the local use of various antibiotics and cortisone ointment ineffective. Lesions diameter of about 1cm, clear boundaries, the edge of the red embankment uplift, black eschar under the ulcer And a small amount of overflow pus Skin biopsy, mycological tests, including direct smear, culture and biochemical tests to support the diagnosis of cryptococcosis, mice intraperitoneal inoculation positive results in patients with general laboratory tests showed no abnormalities, blood, urine, Sputum culture (-), chest radiograph (-), Coccidioidomycosis (-), lumbar puncture was rejected.The patient by 100mg / kg 5-