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目的:中西医结合治疗肠易激综合征,以西药得舒特为对照,从肠道症状和生活质量两方面观察其临床疗效。方法:符合罗马Ⅲ诊断标准的69例肠易激综合征患者,中药1组(以腹泻为主)29例,在西药治疗的基础上加用用疏肝理气,健脾化湿方药治疗,中药2组(以便秘为主)21例,在西药治疗的基础上加用疏肝理气,润肠通便方药治疗,西药对照组18例,予得舒特治疗。3组服药疗程为4周。采用症状等级评分表和SF-36生活质量评价作为判定依据,观察治疗前后各组患者肠道症状及生活质量的变化。结果:①中药1组和中药2组的治疗有效率明显优于对照组,差异有显著性(P<0.05)。②治疗前后中药1组和中药2组患者肠道症状均有显著改善,对照组的腹胀症状无明显改善。中药1组和中药2组对腹痛、大便次数、大便急迫方面的改善作用明显优于对照组。③中药1组和中药2组治疗前后患者躯体疼痛(BP)、总体健康(GH)、活力(VT)、社会功能(SF)、精神健康(MH)维度的积分均有明显提高,具有统计学意义(P<0.05),对照组患者仅活力维度的生活质量得到显著改善,具有统计学差异(P<0.05)。结论:中西医结合治疗肠易激综合征疗效确切,在肠道症状的改善和生活质量的提高两方面都显著优于单一西药治疗组,值得进一步推广。
Objective: Integrative Medicine for the treatment of irritable bowel syndrome, western medicine Shu Shute as a control, from the intestinal symptoms and quality of life were observed two aspects of its clinical efficacy. Methods: According to the Roman Ⅲ diagnostic criteria of 69 cases of irritable bowel syndrome patients, Chinese medicine group 1 (diarrhea dominated) 29 cases, on the basis of Western medicine plus Shugan Qi, spleen Huashi herbs, Chinese medicine Two groups (mainly for constipation) in 21 cases, on the basis of Western medicine plus Shugan Qi, Runchang laxative prescription treatment, western medicine control group of 18 cases, to be Shute treatment. 3 groups medication course of 4 weeks. The symptom rating scale and SF-36 quality of life evaluation were used as the basis of judgment, and the changes of intestinal symptoms and quality of life in each group before and after treatment were observed. Results: ① The effective rate of Chinese traditional medicine 1 group and traditional Chinese medicine group 2 is obviously better than that of the control group (P <0.05). ② Before and after treatment, the intestinal symptoms of Chinese medicine group 1 and traditional Chinese medicine group 2 were significantly improved, while the control group had no obvious improvement of bloating symptoms. Chinese medicine group 1 and traditional Chinese medicine 2 groups on abdominal pain, stool frequency, stool urgency aspects of the improvement was significantly better than the control group. (3) The scores of somatic pain (BP), total health (GH), vitality (VT), social function (SF) and mental health (MH) in Chinese medicine group 1 and traditional Chinese medicine group were significantly increased before and after treatment (P <0.05). The quality of life in the vitality dimension of the control group was significantly improved with statistical significance (P <0.05). Conclusion: Integrative treatment of irritable bowel syndrome curative effect is exact, in the improvement of intestinal symptoms and quality of life are significantly better than single western medicine treatment group, worth further promotion.