矽肺是长期吸入游离二氧化硅粉尘所引起的,以肺脏弥漫性纤维化为主的一种全身性慢性疾患,为了寻找治疗矽肺的有效药物,我们在广筛药物中发现梯络龙对大鼠实验性矽肺具有明显的疗效。梯络龙系由Mayer氏于1970年首次发现的一种低分子口服干扰素诱生剂,具有抗病毒、抗肿瘤以及免疫调节等多种生物活性。国外尚未报导该药有治疗矽肺的作用。本文旨在阐明梯络龙对实验性矽肺的疗效,并探讨其疗效与诱生干扰素能力之间有无平行关系。材料与方法(一)、药品:梯络龙(Tilorone Hydrochloride)由徐州制药厂合成提供。聚I:C(Polyinosinic:Polycytidilicacid)系P—L生化试验公司出品(批号547122)。(二)、病毒株:新城鸡瘟病毒(NDV)B_1株,由美国SLoam-kettering癌症研究所Krim惠赠。在10日龄鸡胚尿囊常规培养,其血凝滴度为1280单位/ml,鸡胚感染 Silicosis is caused by long-term inhalation of free silica dust. It is a systemic chronic disease with diffuse lung fibrosis. In order to find effective drugs for the treatment of silicosis, we have found that in the widescreen drug we have found that Experimental silicosis has a significant effect. It is a low-molecular oral interferon inducer first discovered by Mayer’s in 1970 and has various biological activities such as anti-virus, anti-tumor and immune regulation. It has not been reported in foreign countries that this drug has the effect of treating silicosis. The purpose of this article is to elucidate the therapeutic effect of fluoxetine on experimental silicosis and to explore whether there is a parallel relationship between its efficacy and the ability to induce interferon. Materials and Methods (1) Drugs: Tilorone Hydrochloride was supplied by Xuzhou Pharmaceutical Factory. Poly I: C (Polyinosinic: Polycytidilic acid) was produced by the P-L biochemical test company (Lot No. 547122). (B) Virus strain: Newcastle disease virus (NDV) strain B_1, gifted by Krim, SLoam-kettering cancer research institute in the United States. In the routine culture of 10-day-old chick embryo allantoic, the hemagglutination titer was 1280 units/ml, chicken embryo infection