颠茄合剂是以蒸馏水为溶剂配制而成的非灭菌口服液体制剂,为临床常用解痉药。本制剂含醇量约为4%,不足以起到防腐防发酵的作用,因而在配制及贮存过程中易受微生物污染,使制剂酸败变质。这不但给批量生产带来困难,而且危害病人的身体健康。针对这一现象,我们对本制剂微生物污染 Belladonna mixture is distilled water for the preparation of non-sterile oral liquid preparation, clinical antispasmodic drugs. The preparation contains about 4% of alcohol, not enough to play the role of anti-corrosion anti-fermentation, and therefore in the preparation and storage process susceptible to microbial contamination, the preparation of spoilage. This not only poses difficulties for mass production, but also endangers the health of patients. In response to this phenomenon, we are microbial contamination of the preparation