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米索前列醇对大鼠子宫有明显的收缩作用。米索随着剂量由５００、２０００增至４０００μｇ／ｋｇ，兔子宫内压由弱到强，收缩频率由慢加快。米索５００μｇ／ｋｇ和米非司酮２０００μｇ／ｋｇ合用后对妊娠兔子宫内压加强，收缩频率加快，而米非司酮能提高子宫肌的敏感性。小鼠口服米索的半数有效量（ＥＤ５０）为１６００（９００～２７００）μｇ／ｋｇ，单用口服米非司酮及分别与米索４００、８Ｏ０和１２００μｇ／ｋｇ合用时半数有效量依次为４１３．５、２２６．５、２０６．０和１４２．０μｇ／ｋｇ。米索对大鼠完全无终止妊娠作用；单用口服来非司酮及分别与来索４００、８００和１２００μｇ／ｋｇ合用时半数有效量依次为２４３０．５、５８９．４、４３７．２和３７６．５μｇ／ｋｇ。
Misoprostol on the rat uterus significant contraction. As the dose increased from 500 to 2000 μg / kg, the intrauterine pressure in the uterus decreased from weak to strong, and the frequency of contractions slowed down gradually. In combination with misoprostol 500μg / kg and mifepristone 2000μg / kg, intrauterine pressure in pregnancy increased and the frequency of contractions accelerated, while mifepristone could increase the sensitivity of uterine muscle. The half effective dose of oral administration of misoprostol (ED50) in mice was 1600 (900-2,700) μg / kg. When administered orally with mifepristone alone or in combination with 400, 800 and 1200 μg / .5, 226.5, 206.0 and 142.0 μg / kg. Misoprostol had no effect on the termination of pregnancy in rats. For oral administration of nifepristone alone and in combination with 400,800 and 1200 μg / kg, respectively, the effective doses were 2430.5, 589.4, 437.2 and 376 .5 μg / kg.