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目的分析妊娠特异性皮肤(SDP)患者血细胞及肝功能指标,探讨其变化规律。方法检测SDP患者(实验组)及健康孕妇各80例(对照组)的血细胞及肝功能并比较分析。结果实验组血WBC均值小于对照组,RBC及LYMPH高于对照组;生化检验ALT,GGT,Tbil,Dbil,TBA,PA,Alb高于正常组,ALP及5’-NT低于对照组,差异有统计学意义(P<0.05)。实验组WBC,RBC,NEUT异常例数低于正常组,生化GGT,ALP,5’-NT异常例数明显高于正常孕妇,异常比率的比较有统计学意义。结论 SDP患者与正常孕妇比较营养指标高,炎症程度低,肝损伤及胆汁瘀积严重,胎盘功能低下。需要进一步增加临床亚型的样本量,并应用纵向序贯的研究方法对孕期相关的指标作进一步探讨。
Objective To analyze the blood cells and liver function indexes of pregnancy-specific skin (SDP) patients and to explore their changing rules. Methods Blood cells and liver function in 80 SDP patients (experimental group) and healthy pregnant women (control group) were detected and compared. Results The mean blood WBC in the experimental group was lower than that in the control group, and RBC and LYMPH were higher than those in the control group. The levels of ALT, GGT, Tbil, Dbil, TBA, PA and Alb in the experimental group were higher than those in the normal group There was statistical significance (P <0.05). The abnormal number of WBC, RBC and NEUT in the experimental group was lower than that in the normal group, and the number of biochemical GGT, ALP and 5’-NT abnormalities in the experimental group was significantly higher than that in the normal pregnant women. The abnormal ratio was statistically significant. Conclusion Compared with normal pregnant women, SDP patients have higher nutrition index, lower degree of inflammation, severe liver injury and cholestasis, and lower placental function. Need to further increase the sample size of the clinical subtype, and the application of longitudinal sequential research methods for pregnancy-related indicators for further discussion.