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用于单一和联合治疗卵巢癌的有效化疗药虽有多种,但大部分病人复发或死于转移,故需要更好的治疗方案。顺铂(DDP)和六甲三聚氰胺(H MM)用于未治疗的卵巢癌病人,有效率分别为35和31%,而用于曾给过化疗病人的有效率,分别为26和28%。本文报导13例治疗后复发病人用DDP_+HMM联合治疗的效果。选择的病人均为经病理证实,存活超过6周,肝、肾、心和骨髓功能正常,有可测到的病变和化疗失败但未用过DDP或HMM治疗者。13例病人中,Ⅲ期9例,Ⅳ期4例,曾经用多种治疗包括烷化剂联合化疗12例或多种单一药物1例。其它治疗
There are many available chemotherapeutic agents for single and combined ovarian cancer, but most patients will relapse or die from metastasis, requiring better treatment. Cisplatin (DDP) and hexamethylmelamine (HMM) were used in untreated ovarian cancer patients with efficiencies of 35 and 31%, respectively, and 26 and 28%, respectively, for those who had given chemotherapy. This article reports 13 cases of relapsed patients treated with DDP HM HMM combined effect. All patients were pathologically confirmed to have survived for more than 6 weeks and had normal liver, kidney, heart and bone marrow function with measurable lesions and failed chemotherapy but no DDP or HMM treatment. Of the 13 patients, 9 were in stage III and 4 were in stage IV, and 12 had been treated with a combination of alkylating agents and chemotherapy or 1 in multiple single agents. Other treatment