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目的 :探讨乳腺分泌型癌的临床病理特征、诊断和鉴别诊断要点。方法 :分析 14例分泌型乳腺癌患者的临床病理资料 ,进行光镜观察 ,部分病例进行组织化学及免疫组化染色 ,并复习文献。结果 :分泌型乳腺癌临床及病理大体观察与其他类型乳腺癌无明显区别 ,主要表现为乳房内肿块 ,多位于乳晕区 ,大体观察肿物大多边界不清、质地硬 ,光镜下肿瘤细胞主要排列成实性、小囊性和导管性三种结构 ,瘤细胞有颗粒性嗜酸性胞质 ,瘤细胞内外有大量均质嗜伊红PAS阳性分泌物。腋下淋巴结转移较少 (2 / 14)。无局部复发或远处转移 (随访 3～ 14年 )。结论 :分泌型乳腺癌为罕见且预后较好的乳腺癌 ,确诊必须依靠病理检查。
Objective: To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of breast secretory carcinoma. METHODS: The clinical and pathological data of 14 patients with secretory breast cancer were analyzed. Light microscopy was performed. Histochemical staining and immunohistochemical staining were performed in some cases. The literature was reviewed. RESULTS: The clinical and pathological findings of secretory breast cancer were not significantly different from those of other types of breast cancer. The main manifestations were intramammary masses, mostly located in the areola area. Grossly observed tumors had mostly unclear borders and hard texture. The majority of tumor cells under light microscope were tumor cells. Arranged into solid, small cystic and ductal three structures, tumor cells have granular eosinophilic cytoplasm, tumor cells inside and outside a large number of homogeneous eosinophil PAS positive secretions. Less axillary lymph node metastases (2 / 14). No local recurrence or distant metastasis (Follow-up 3 to 14 years). Conclusion: Secretory breast cancer is a rare breast cancer with good prognosis. The diagnosis must rely on pathological examination.