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细胞凋亡对组织发育和自身稳定具有重要调节作用。为了阐明Ｂ细胞受体 (ＢＣＲ)介导的凋亡机制 ,研究者用人Ｂｕｒｋｉｔｔ淋巴瘤细胞株ＢＬ6 0做为研究生发中心Ｂ细胞耐受的实验模型。实验结果指出 :①ＴＮＦ相关凋亡诱导配体 (ＴＲＡＩＬ)的两种受体 ,即ＴＲＡＩＬ Ｒ1 、 Ｒ
Apoptosis plays an important regulatory role in tissue development and self-stability. Burkitt lymphoma cell line BL6 0 was used as an experimental model for studying B cell tolerance in germinal center in order to elucidate the mechanism of B cell receptor (BCR) -mediated apoptosis. The experimental results indicate that: ①TNF-related apoptosis-inducing ligand (TRAIL) receptors, TRAIL R1, R