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作者报告三例经手术切除和放疗后复发的脑胶质瘤患者,经卡氮芥(BCNU)治疗后均获较长期存活且无后遗症。例一为四脑室室管膜瘤,经手术切除及放射治疗后复发,用卡氮芥按90毫克/平方米/天的剂量,连用三日为一疗程,每隔6～8周重复一疗程,在出现骨髓积蓄中毒时减少剂量,共用卡氮芥三日疗法十三个疗程,化疗后好转,恢复手工劳动。例二为左顶叶退变的(anaplastic)星状细胞瘤,经手术部分切除及放射治疗后三月,脑血管造影显示仍有大量残存肿瘤,用卡氮芥按100毫克/平方米/日的剂量,每隔6～8周连用三日,共接受10个疗程卡氮芥治疗。语言及运动功能持续改善,并在终止治疗13个月后恢复正常。脑血管造影及脑扫描均显示原来异常改变有明显改善。例三为左颞叶星状细胞瘤,术后继以放射治疗情况良好,恢复工
The authors report that three patients with gliomas who relapsed after surgical resection and radiotherapy had long-term survival without sequelae after treatment with BCNU. One case of four-ventricle ependymoma after surgical resection and recurrence of radiation therapy, with carbamide mustard at a dose of 90 mg / m / day, once every three days for a course of treatment, every 6 to 8 weeks to repeat a course of treatment , Reduce the dose in the event of bone marrow poisoning, three-day course of treatment shared Carnation mustard thirteen courses of chemotherapy improved after the resumption of manual labor. Case 2 is anaplastic astrocytoma in the left parietal lobe. Surgical resection and radiotherapy for three months after cerebrovascular angiography showed that there were still a large number of residual tumors. Carmicarbazone at 100 mg / m 2 / day Dose, once every 6 to 8 weeks for three days, received a total of 10 courses of treatment of carmustine. Language and motor function continued to improve and returned to normal 13 months after termination of treatment. Cerebral angiography and brain scan showed that the original abnormal changes have been significantly improved. Three cases of left temporal lobular astrocytoma, followed by radiotherapy in good condition, resume work