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目的观察甘精胰岛素治疗初诊老年2型糖尿病患者的临床效果及安全性。方法将本院自2010年1月~2012年1月收治的90例2型糖尿病患者随机分为观察组(45例)与参考组(45例),观察组患者采用甘精胰岛素治疗,参考组患者采用诺和锐胰岛素治疗,比较两组治疗前后血糖变化,记录患者治疗期间低血糖发生情况,治疗12周后对两组糖化血红蛋白水平进行记录。结果相较治疗前,两组患者血糖均得到明显控制(P<0.05);观察组患者血糖控制效果明显优于参考组(P<0.05);治疗2周后观察组患者糖化血红蛋白水平明显优于参考组,比较差异有统计学意义(P<0.05);观察组患者低血糖发生率明显低于参考组(P<0.05)。结论甘精胰岛素治疗初诊老年2型糖尿病患者能够实现良好的降糖效果,促进胰岛功能的恢复,同时低血糖发生率低,安全高效,值得推广使用。
Objective To observe the clinical effect and safety of insulin glargine in the treatment of newly diagnosed type 2 diabetic elderly patients. Methods Ninety patients with type 2 diabetes who were admitted to our hospital from January 2010 to January 2012 were randomly divided into observation group (45 cases) and reference group (45 cases). Patients in observation group were treated with insulin glargine, The patients were treated with Novo Rui insulin, the changes of blood glucose before and after the treatment were compared, the occurrence of hypoglycemia during the treatment was recorded, and the levels of HbA1c were recorded after 12 weeks of treatment. Results Compared with the reference group (P <0.05), the blood sugar of the two groups was significantly controlled before treatment (P <0.05). The level of glycosylated hemoglobin in the observation group was significantly better than that of the reference group (P <0.05). The incidence of hypoglycemia in the observation group was significantly lower than that in the reference group (P <0.05). Conclusion Glargine treatment of patients with newly diagnosed type 2 diabetes mellitus can achieve good hypoglycemic effect, promote the recovery of pancreatic islet function, low incidence of hypoglycemia, safe and efficient, it is worth to promote the use.