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本文根据三个治疗中心(5年时间)对已诊断为胎儿结构性缺陷和染色体异常之间的关系进行了回顾性和随访研究。在已确诊的386例结构性缺陷胎儿中,对170例胎儿进行了产前染色体分析(44%),其根据如下:(1)与已知染色体异常相关的特殊结构性缺陷:如心脏结构性异常、12指肠闭锁、脐突出或水囊状淋巴管瘤(36%);(2)多发性结构缺陷(22%);(3)宫内生长迟缓(IUGR),以上腹围低于第5百分位(19%);(4)胎儿非免疫性积水(6%);(5)罕见的缺陷:如腹部囊肿、面裂(3%)。产前细胞遗传学分析主要是取羊水161例,其次取胎儿尿4例,
This retrospective and follow-up study of the relationship between fetal structural defects and chromosomal abnormalities was based on three treatment centers (5 years). Prenatal chromosome analysis (44%) was performed on 170 fetuses in 386 confirmed cases of structural defect fetuses based on the following: (1) Specific structural defects associated with known chromosomal abnormalities such as cardiac structural (12%); (3) intrauterine growth retardation (IUGR), above the abdominal circumference lower than the first 5th percentile (19%); (4) Fetal non-immune hydrops (6%); and (5) rare defects such as abdominal cysts and facial cleft (3%). Prenatal cytogenetic analysis is to take 161 cases of amniotic fluid, followed by fetus in 4 cases,