论文部分内容阅读
本文对胶质瘤病人及对照组分别检测了周围血中Ｔ淋巴细胞亚群及β２－微球蛋白（β２－ｍＧ）含量及脑脊液中β２－ｍＧ含量，结果表明，脑胶质瘤病人ＣＤ４＋（辅助／诱导性Ｔ淋巴细胞）降低，ＣＤ８＋（细胞毒／抑制性Ｔ淋巴细胞）增高，ＣＤ４＋／ＣＤ８＋降低，与对照组有显著差异（Ｐ＜０．０５），脑胶质瘤病人血及脑脊液中β２－ｍＧ含量增高与对照组比较有显著差异（Ｐ＜０．０５）。脑胶质瘤病人β２－ｍＧ增高与ＣＤ４＋／ＣＤ８＋比值之间呈负相关性。本组实验证明，脑胶质瘤患者存在细胞免疫功能低下，且β２－ｍＧ含量与细胞免疫功能呈负相关。β２－ｍＧ可反映细胞免疫功能状态。
In this study, peripheral blood T-lymphocyte subsets, β2-microglobulin (β2-mG) content, and β2-mG content in cerebrospinal fluid were measured in glioma patients and controls, and the results showed that CD4+ was present in glioma patients. Helper/inducible T lymphocytes decreased, CD8+ (cytotoxic/inhibitory T lymphocytes) increased, and CD4+/CD8+ decreased, which was significantly different from the control group (P<0.05). Blood and cerebrospinal fluid in glioma patients The increase of β2-mG content was significantly different from that of the control group (P<0.05). There was a negative correlation between β2-mG elevation and CD4+/CD8+ ratio in glioma patients. This group of experiments has demonstrated that patients with glioma have low cellular immune function, and β2-mG content is negatively correlated with cellular immune function. β2-mG can reflect the cellular immune function status.