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目的探讨老年男性2型糖尿病(T2DM)患者血清内脂素水平与糖脂代谢的关系。方法采用酶联免疫吸附试验测定老年男性T2DM患者61例(A组)和非糖尿病老年男性患者57例(B组)血清内脂素水平,同时测定两组血压、空腹血糖、血脂水平,并计算胰岛素抵抗指数(HOMA-IR)、体重指数和腰臀比。结果 A组内脂素水平高于B组[(21.3±5.4)μg/L vs.(14.7±5.2)μg/L](P<0.05),内脂素水平与腰臀比和体重指数呈正相关(P<0.05)。结论老年男性T2DM患者血清内脂素水平增高;内脂素可能参与老年男性T2DM肥胖、胰岛功能受损的发生发展。
Objective To investigate the relationship between serum visfatin and glucose and lipid metabolism in elderly male patients with type 2 diabetes mellitus (T2DM). Methods The levels of serum visfatin in 61 elderly patients with T2DM (group A) and 57 non-diabetic elderly men (group B) were determined by enzyme-linked immunosorbent assay (ELISA). Blood pressure, fasting blood glucose, Insulin resistance index (HOMA-IR), body mass index and waist-to-hip ratio. Results The level of visfatin in group A was significantly higher than that in group B [(21.3 ± 5.4) μg / L vs. (14.7 ± 5.2) μg / L, P <0.05) (P <0.05). Conclusion The serum level of visfatin in elderly men with T2DM is increased; visfatin may be involved in the development of T2DM obesity and impaired pancreatic islet function in elderly men.