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目的:探讨不同糖代谢人群胰岛素抵抗和胰岛β功能。方法:1109例行OGTT及胰岛素释放试验,按照血糖结果分为正常糖耐量(NGR)组161例,糖调节异常(IGR)组276例,糖尿病(DM)组672例,均按稳态模型计算胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)早相胰岛素分泌指数(△I30/△G30)评价。结果:NGR与IGR组、DM组相比HOMA-IR有显著差异性(P=0.032,P<0.000);HOMA-β有显著差异性(P<0.000,P<0.000):而NGR与IGR组相比△I30/△G30无差异性(P=0.298):NGR与DM组相比△I30/△G30有差异性(P=0.025);IGR组与DM组相比HOMA-IR有显著差异性(P<0.000):HOMA-β有显著差异性(P<0.000);△I30/△G30无差异性(P=0.266)结论:HOMA-IR、HOMA-β在不同糖代谢结果不同,具有统计学意义,是评估糖代谢人群胰岛功能的良好指标,△I30/△G30糖代谢正常人群与糖尿病人群△I30/△G30相比具有差异性,提示关注早相分泌是临床治疗和干预的方向之一。
Objective: To investigate the insulin resistance and pancreatic β function in different glucose metabolism population. Methods: 1109 routine OGTT and insulin release test were divided into normal glucose tolerance (NGR) group, 161 patients, 276 patients with abnormal glucose regulation (IGR) and 672 patients with diabetes mellitus (DM) Insulin resistance index (HOMA-IR), insulin secretion index (HOMA-β) early phase insulin secretion index (△ I30 / △ G30) evaluation. Results: Compared with IGR group and DM group, HOMA-IR was significantly different (P = 0.032, P <0.000); HOMA-β was significantly different (P <0.000, P <0.000) Compared with I30 / △ G30 no difference (P = 0.298): NGR compared with DM group △ I30 / △ G30 difference (P = 0.025); IGR group compared with DM group HOMA-IR significant difference (P <0.000): HOMA-β was significantly different (P <0.000); △ I30 / △ G30 no difference (P = 0.266) Conclusion: HOMA-IR, HOMA-β results in different glucose metabolism, with statistics The significance of learning is a good indicator to evaluate the islet function in the population of glucose metabolism. The difference between the △ I30 / △ G30 normal glucose metabolism group and the △ I30 / △ G30 diabetic group suggest that attention to the early phase secretion is the direction of clinical treatment and intervention one.