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肿瘤主动特异性免疫治疗疗效与肿瘤瘤苗免疫原性的强弱有直接密切的关系.作者认为细菌性佐剂的应用仍不失为制备强免疫原性瘤苗的有效方法,并以胞内寄生性细菌——李斯特菌为佐剂性细菌,通过碱毒性自然感染或溶壁后原生质体与瘤细胞融合的手段制备得到了李斯特菌瘤苗
There is a direct and close relationship between the efficacy of tumor-specific active immunotherapy and the immunogenicity of tumor vaccines. The authors believe that the application of bacterial adjuvants is still an effective method for the preparation of strong immunogenic tumor vaccines, and intracellular parasitic Bacteria - Listeria monocytogenes is an adjuvant bacterium. Listeria monocytogenes are prepared by means of natural toxicity or fusion of protoplasts and tumor cells after lysis.