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目的：观察肝细胞生长因子（ＨＧＦ）合并常用综合疗法治疗慢性重症肝炎的疗效。方法：治疗组３２例（男性２５例，女性７例；年龄４２±ｓ１４ａ），ＨＧＦ１２０－１６０ｍｇ加１０％葡萄糖注射液２５０ｍＬ静脉滴注，每日１次，加常用综合疗法。对照组２８例（男性２６例，女性２例；年龄４５±１２ａ），用常用综合疗法（１０％葡萄糖注射液２５０ｍＬ，１０％氯化钾注射液５ｍＬ，维生素Ｃ注射液３ｇ混合静脉滴注，肝病用１５－氨基酸注射液２５０ｍＬ，静脉滴注，每日１次）。疗程均为２ｍｏ。结果：ＨＧＦ治疗组对改善症状，体征，降低胆红素，提高白、球蛋白比率均明显优于对照组，治疗组病死率（３８％），显著低于对照组（６８％）。结论：ＨＧＦ合并常用综合疗法治疗慢性重症肝炎疗效满意。
Objective: To observe the curative effect of hepatocyte growth factor (HGF) combined with commonly used comprehensive therapy in treating chronic severe hepatitis. Methods: The treatment group of 32 patients (25 males and 7 females; age 42 ± s14a), HGF120-160mg plus 10% glucose injection 250mL intravenous infusion, once daily, plus commonly used combination therapy. The control group of 28 patients (26 males, 2 females; age 45 ± 12a), with the commonly used combination therapy (10% glucose injection 250mL, 10% potassium chloride injection 5mL, vitamin C injection 3g mixed intravenous infusion, Liver disease with 15-amino acid injection 250mL, intravenous infusion, once daily). Treatment are 2mo. Results: HGF treatment group was significantly better than the control group in improving symptoms and signs, reducing bilirubin, improving white and globulin ratio, and the mortality rate was 38% in the treatment group, which was significantly lower than that in the control group (68%). Conclusion: HGF combined with commonly used comprehensive treatment of chronic severe hepatitis with satisfactory results.