Direct numerical simulation (DNS) of decaying compressible isotropic turbulence at tur-bulence Mach numbers of Mt = 0.2-0.7 and Taylor Reynolds numbers of 72 and 153 is per-formed by using the 7th order upwind-biased difference and 8th order center difference schemes.Results show that proper upwind-biased difference schemes can release the limit of "start-up"problem to Mach numbers.Compressibility effects on the statistics of turbulent flow as well as the mechanics of shockletsin compressible turbulence are also studied, and the conclusion is drawn that high Mach numberleads to more dissipation. Scaling laws in compressible turbulence are also analyzed. Evidence isobtained that scaling laws and extended self similarity (ESS) hold in the compressible turbulentflow in spite of the presence of shocklets, and compressibility has little effect on scaling exponents.