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为了给临床选择乳腺癌术后治疗方案提供可靠依据，探讨乳腺癌预后因素的判断指标。对６０例乳腺癌（３９例伴腋淋巴结转移）组织蜡块，采用ＬＳＡＢ法标记ＰＣＮＡ、ｐ５３，亲和组化法标记ＥＲ、ＰＲ。结果显示ＰＣＮＡ表达强度为＋＋～＋＋＋时，其阳性率与病理分级、淋巴结转移及转移数目呈正相关。ＥＲ、ＰＲ阳性表达与病理分级、淋巴结转移呈负相关。ｐ５３的表达与病理分级、淋巴结转移无明显关系。提示ＰＣＮＡ、ＥＲ、ＰＲ是判断乳腺癌预后的有效指标，ＰＣＮＡ阳性强度为＋＋～＋＋＋，ＥＲ、ＰＲ阴性时预后差，ｐ５３作为乳腺癌的预后指标不理想。
In order to provide a reliable basis for the clinical treatment of breast cancer after surgery, to determine the indicators of prognosis of breast cancer. Forty cases of breast cancer (39 cases with axillary lymph node metastasis) were organized into wax blocks. The LSAB method was used to label PCNA and p53. Affinity and histochemistry was used to label ER and PR. The results showed that when the expression intensity of PCNA was ++ to +++, the positive rate was positively correlated with pathological grade, lymph node metastasis, and number of metastases. The positive expression of ER and PR was negatively correlated with pathological grade and lymph node metastasis. There was no significant relationship between the expression of p53 and pathological grade and lymph node metastasis. It is suggested that PCNA, ER, and PR are effective indexes to judge the prognosis of breast cancer. The positive intensity of PCNA is ++ to +++. If ER and PR are negative, the prognosis is poor. The prognosis of breast cancer is not ideal.