肿瘤是威胁人类健康的恶性疾病,在其发生发展过程中,T细胞活化和耐受的免疫调节起着至关重要的作用,其中B7-CD28家族成员介导的T细胞共刺激信号转导,不仅在启动、增强和维持T细胞应答中提供了关键的正性信号,而且还可提供重要的负性信号来限制、终止或削弱T细胞的免疫应答。随着新的共刺激信号分子不断被发现及相关 Tumor is a malignant disease that is a threat to human health. T cell activation and tolerated immune regulation plays a crucial role during the development of T-cell. T-cell co-stimulated signal transduction mediated by B7-CD28 family member, Not only does it provide a key positive signal in initiating, enhancing and maintaining T cell responses, but it can also provide important negative signals to limit, terminate or attenuate T cell immune responses. As new costimulatory signaling molecules continue to be found and correlated