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目的 :分析和探讨氟喹诺酮类药的临床应用与不良反应。方法 :对2015年1月-2017年3月我院收治的540例氟喹诺酮类药物抗感染患者临床资料进行了回顾性分析,分析患者不良反应发生率及不良反应。结果 :540例患者,有48例患者产生用药后不良反应。左氧氟沙星、氧氟沙星、环丙沙星和加替沙星不良反应比率分别8.7%、8.1%、9.8%和9.5%,其中环丙沙星不良反应发生率最高。大部分产生不良反应的患者与静脉给药有关。患者的不良反应包括过敏反应、胃肠道反应、血糖波动、神经系统反应、血液系统反应、泌尿系统反应和心血管系统反应,其中过敏反应和胃肠道反应发生率较高,分别为39.6%和20.8%。结论 :临床上需进一步加深对氟喹诺酮类药不良反应的认识,合理用药,以降低药物不良反应发生率。
Objective: To analyze and discuss the clinical application and adverse reactions of fluoroquinolones. Methods: The clinical data of 540 patients with fluoroquinolones in our hospital from January 2015 to March 2017 were retrospectively analyzed, and the incidence of adverse reactions and adverse reactions in patients were analyzed. Results: In 540 patients, 48 patients developed adverse reactions after treatment. The adverse reaction rates of levofloxacin, ofloxacin, ciprofloxacin and gatifloxacin were 8.7%, 8.1%, 9.8% and 9.5% respectively, of which ciprofloxacin had the highest incidence of adverse reactions. Most adverse reactions in patients with intravenous administration. Adverse reactions of patients included anaphylaxis, gastrointestinal reaction, blood glucose fluctuation, nervous system reaction, hematological response, urinary system reaction and cardiovascular system reaction, in which the incidence of allergic reaction and gastrointestinal reaction were higher, which were 39.6% And 20.8%. Conclusion: It is necessary to further deepen the understanding of adverse reactions of fluoroquinolones in clinical practice and rational use of drugs to reduce the incidence of adverse drug reactions.