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目的对西沙掘海绵Dysidea sp.进行化学成分研究。方法运用正相硅胶柱色谱、反相ODS柱色谱、凝胶Sephadex LH-20柱色谱以及高效液相色谱(HPLC)等多种分离手段对西沙掘海绵Dysidea sp.化学成分进行分离纯化;并通过理化性质、波谱学数据等结构信息鉴定其化合物的结构。结果从西沙掘海绵Dysidea sp.中分离鉴定了8个化合物,分别为dictyoceratinC(1)、dactyloquinone B(2)、aminoquinone(3)、dictyoceratin A(4)、dactyloquinone D(5)、dactyloquinone E(6)、(1R*,2E,4R*,7E,10S*,11S*,12R*)-10,18-diacetoxydolabella-2,7-dien-6-one(7)和α,β-unsaturated ester(8)。结论化合物1~6和8均为首次从该属海绵中分离得到。
Objective To study the chemical constituents of Dysidea sp. Methods The chemical constituents of Dysidea sp. Were isolated and purified by normal-phase silica gel column chromatography, reverse phase ODS column chromatography, gel Sephadex LH-20 column chromatography and high performance liquid chromatography (HPLC) Physical and chemical properties, spectral data and other structural information to identify the structure of its compounds. Results Eight compounds were isolated from Dysidea sp. And identified as dictyoceratin C (1), dactyloquinone B (2), aminoquinone (3), dictyoceratin A (4), dactyloquinone D (5) and dactyloquinone E ), 10,18-diacetoxydolabella-2,7-dien-6-one (7) and alpha, beta-unsaturated ester (8) ). Conclusion Compounds 1 ~ 6 and 8 were isolated from the sponge for the first time.