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目的探讨氯吡格雷(波立维)与阿司匹林(拜耳)联合用药用在治疗不稳定型心绞痛(UPA)中的疗效、安全性及远期心血管事件的发生率。方法将我院210例不稳定型心绞痛患者随机分成2组,实验组106例,服用拜耳100mg,1次/d,再服用波立维,首次剂量300mg,维持剂量75mg,1次/d;对照组104例,仅服用拜耳,持续治疗时间均一年。结果观察组有效率为85%高于对照组有效率73%,两组有效率比较差异有统计学意义(P<0.05)。心肌梗死的发生率,实验组11%、对照组17%。实验组出现出血的患者为6%,略微多于对照组4%,但均未出现严重的出血。结论波立维与阿司匹林联合应用在UPA的治疗效果及预后方面明显优于单独应用阿司匹林。
Objective To investigate the efficacy, safety and long-term cardiovascular events in combination with clopidogrel and aspirin (Bayer) in the treatment of unstable angina pectoris (UPA). Methods 210 patients with unstable angina pectoris in our hospital were randomly divided into two groups. The experimental group consisted of 106 patients, taking Bayer 100mg once a day, and then taking the bolivian, the first dose of 300mg, the maintenance dose of 75mg, 1 / d; control group 104 cases, taking Bayer alone, continuous treatment for one year. Results The effective rate of observation group was 85% higher than that of control group, the effective rate was 73%. There was significant difference between two groups (P <0.05). The incidence of myocardial infarction was 11% in the experimental group and 17% in the control group. Bleeding in the experimental group of patients was 6%, slightly more than 4% of the control group, but no serious bleeding. Conclusion The combination of berberine and aspirin is superior to aspirin alone in the treatment and prognosis of UPA.