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用环磷酰胺、甲氨蝶吟及氟脲嘧啶联合化疗(CMF)或CMF加长春新碱和强的松联合化疗(CMFVP)无效的病人,或用CMF/CMFVP作为辅助性化疗后复发的病人,持续输注阿霉素(A)和长春碱(V)是有效的第二线治疗方案。作者等评价了19例停经后、3例停经前的乳腺癌病人。其中肿瘤转移在3处以上器官的为10人,少于2处的为12人。这些病人中用过CMF/CMFVP化疗的为13人,用CMF/CMFVP为辅助化疗的为9人。通过硅橡胶质的锁骨下导管给药,每一疗程的第1～4天持续输注长春碱1.4 mg/m~2/24h,第5～6天
Patients who failed with cyclophosphamide, methotrexate and fluorouracil combined chemotherapy (CMF) or CMF plus vincristine plus prednisone (CMFVP), or patients who relapsed after adjuvant chemotherapy with CMF/CMFVP Continuous infusions of adriamycin (A) and vinblastine (V) are effective second-line treatment options. The authors evaluated 19 patients with postmenopausal breast cancer and 3 patients with premenopausal breast cancer. Of these, 10 were tumor metastases in more than 3 organs, and 12 were in less than 2 tumors. Thirteen of these patients had CMF/CMFVP chemotherapy, and nine had CMF/CMFVP adjuvant chemotherapy. Through silicone-based subclavian administration, vinblastine 1.4 mg/m~2/24 h was continuously infused on the first 4 days of each treatment course, and the 5th to 6th days