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白光或绿光照射亲脂性染料部花青(MC540)介导的光动力学效应对白血病、淋巴瘤等肿瘤细胞有广谱而高效的杀伤作用。杀伤机制可能主要由所产生的单态氧等对MC540结合部位的胞膜结构和功能的破坏.造成细胞死亡.杀伤作用没有细胞周期特异性,对耐药性肿瘤细胞同样有效.对正常造血干细胞损伤较轻,体外骨髓净化后移植能恢复造血,没有毒、副反应.单用或与其他净化方法合用均不失为较有前途的净化措施。
White light or green light irradiation lipophilic dyes Department of cyanine (MC540)-mediated photodynamic effects on leukemia, lymphoma and other tumor cells have a broad spectrum and efficient killing effect. The killing mechanism may be mainly caused by the destruction of the membrane structure and function of the MC540 binding site by the generated singlet oxygen and the like, causing cell death. The killing effect is not specific to the cell cycle and is also effective for drug-resistant tumor cells. For normal hematopoietic stem cells The injury is lighter. After bone marrow purification in vitro, the transplantation can restore hematopoiesis. There is no toxicity or side effects. It is a promising purification measure either alone or in combination with other purification methods.